| Table1. Primary target genes up regulated by p53 | |||||||||||||
| Accession | Ratio of gene expression at specific time points | ||||||||||||
| No. | |||||||||||||
| -CHX | +CHX | ||||||||||||
| hr. | 2 | 6 | 12 | 24 | 2 | 4 | 6 | 9 | 12 | ||||
| Apoptosis | G(47) | G(38) | G(9) | ||||||||||
| X63717 | Fas/APO-1 cell surface antigen | + | + | 2.2 | 5.6 | 7.9 | 8.3 | 3.2 | 6.8 | 3.3 | 5.7 | 9.8 | |
| U82987 | Bcl-2 binding component 3 (bbc3) | + | + | 6.2 | 16.5 | 16.8 | 8.4 | 7.6 | 13.4 | 28.5 | 32.5 | 30.5 | |
| U00115 | Bcl-6 | + | + | 2.5 | 3.3 | 5.8 | 6.5 | 3.7 | 4.7 | 6.1 | 6 | 6.8 | |
| U16811 | Bak | + | + | 4 | 7 | 4.4 | 6.8 | 1 | 2.3 | 4.5 | 4.7 | 7.4 | |
| Cell Cycle | |||||||||||||
| U09579 | p21 WAF1 | + | + | 4.3 | 17.98 | 16.9 | 12.97 | 3.5 | 6.7 | 9.2 | 8.2 | 7.4 | |
| D90070 | ATL derived PMA responsive peptide | + | + | 4 | 4.5 | 2.8 | 4.1 | 1.8 | 3.5 | 3.4 | 4.3 | 6.1 | |
| M60974 | GADD45 | + | 2.3 | 3.2 | 3.4 | 3.6 | 1.6 | 1.6 | 2.1 | 2.1 | 2 | ||
| DNA Repair/Replication | |||||||||||||
| U72649 | BTG2 | + | + | 3 | 4.9 | 4.8 | 5.2 | 11 | 15.9 | 20.1 | 17.9 | 16.5 | |
| U18300 | Damage-specific DNA binding protein | + | + | 1.3 | 4 | 5.4 | 7.8 | 1.1 | 2.6 | 8.6 | 6.1 | 9.4 | |
| U90551 | Histone 2A-like protein | + | + | 2.6 | 2.6 | 2.5 | 3.5 | 1.7 | 3.1 | 4.5 | 8.8 | 16.7 | |
| M15796 | PCNA | + | 2.3 | 3.9 | 5.3 | 5.3 | 1.7 | 1.4 | 1.7 | 1.9 | 3.1 | ||
| Receptors/ECM | |||||||||||||
| X72012 | Endoglin | + | 21.7 | 15.2 | 7.9 | 6.8 | 3.4 | 1 | 14 | 6.9 | 1 | ||
| U16306 | versican | + | + | 1 | 5.2 | 11.9 | 16.6 | 1 | 2 | 2.7 | 6.8 | 13.3 | |
| M21904 | Heavy chain 4F2 | + | 7.7 | 6.5 | 8.2 | 6.1 | 0.9 | 1 | 1.6 | 1.3 | 1.4 | ||
| AF010193 | SMAD7 | + | 3.6 | 1.9 | 3.9 | 3.1 | 1.9 | 1.8 | 1.5 | 1.5 | 1.6 | ||
| Growth Factors/Inhibitors | |||||||||||||
| AB000584 | TGF-Beta Superfamily Protein | + | + | 3.5 | 41.6 | 67.2 | 50.1 | 11.5 | 16 | 41.4 | 33.6 | 32.4 | |
| M62402 | IGFBP6 | + | + | 17.5 | 17.68 | 18.5 | 17.6 | 22.3 | 13.9 | 27.8 | 25.4 | 28.95 | |
| L42379 | Quiescin/QSCN6 | + | 2.7 | 2.4 | 2.5 | 2.8 | 1.3 | 2.2 | 2.3 | 2.3 | 1.7 | ||
| X97324 | Adipophilin | + | 5.2 | 6.3 | 7.1 | 10 | 1.5 | 1.9 | 1.7 | 1.9 | 3.8 | ||
| U72263 | Multiple exostoses type II protein | + | 2.9 | 2.7 | 3.1 | 6.2 | 1.5 | 2 | 1.4 | 1.8 | 3.2 | ||
| Cytoskeleton/Cell Adhesion | |||||||||||||
| X13839 | Vascular smooth muscle alpha-actin | + | + | 6.5 | 14.6 | 44.3 | 98.3 | 6.4 | 9 | 18.9 | 18.4 | 26.9 | |
| Z49989 | Smoothelin | + | + | 3.7 | 4.3 | 3.9 | 3.5 | 1.7 | 2.2 | 4.6 | 4.1 | 3.4 | |
| X05608 | Neurofilament subunit NF-L | + | + | 3 | 7.7 | 16.6 | 32 | 5 | 8.8 | 9.6 | 16.8 | 32.2 | |
| D82345 | NB Thymosin beta | + | + | 2.4 | 3.4 | 4.2 | 5.4 | 1.6 | 2.5 | 3.8 | 2.8 | 3.9 | |
| X93510 | LIM domain protein | + | 4.5 | 5.5 | 4.3 | 5.6 | 4.3 | 2.4 | 9.3 | 3.8 | 1 | ||
| Metabolism | |||||||||||||
| U24389 | Lysyl oxidase-like protein | + | + | 16.7 | 17.5 | 23 | 22.9 | 5.5 | 4.2 | 9.7 | 8.3 | 6.9 | |
| L41668 | UDP-Galactose 4 epimerase (GALE) | + | + | 4.2 | 3.6 | 3.2 | 4.4 | 3.2 | 3.7 | 5.1 | 3.4 | 2.8 | |
| Y12556 | cAMP activated Protein Kinase B | + | + | 4 | 1 | 19.7 | 22.2 | 1 | 3.1 | 3.1 | 7.1 | 37.5 | |
| U05572 | Lysosomal Mannosidase alpha B | + | 9.2 | 2 | 7 | 15.9 | 6.5 | 5.6 | 13.9 | 13 | 7.2 | ||
| Y09616 | Carboxylesterase (liver) | + | + | 2.3 | 4.1 | 5.9 | 9.1 | 1.9 | 2.5 | 3 | 3.4 | 3.6 | |
| U78735 | ABC3 | + | 4.5 | 3 | 2.8 | 3.6 | 1.9 | 2 | 1.9 | 1.4 | 1.1 | ||
| M20902 | Apolipoprotein C-I (VLDL) | + | 3.1 | 3.9 | 2.9 | 4.1 | 2.1 | 2.9 | 2.3 | 2.2 | 1.7 | ||
| U20325 | CART | + | 2.8 | 3.9 | 3 | 3.3 | 1.3 | 1.7 | 2.1 | 1.3 | 1.9 | ||
| M12625 | Lecithin-cholesterol acyltransferase | + | 1.4 | 2.9 | 3 | 3 | 0.8 | 1.4 | 3.6 | 2.6 | 2.4 | ||
| D87292 | Rhodanese | + | 7.7 | 4.9 | 5.4 | 10.5 | 1.6 | 1.6 | 1.7 | 1.3 | 1.2 | ||
| Neuronal Growth | |||||||||||||
| U35139 | NECDIN related protein | + | 3.2 | 1 | 3 | 15.7 | 5.8 | 4.9 | 2.7 | 4.8 | 5.5 | ||
| M96740 | NSCL-2 gene | + | + | 1 | 4.2 | 10.1 | 12.6 | 2.6 | 2 | 4.8 | 7 | 11 | |
| U60062 | FEZ1-T gene | + | + | 1 | 2.7 | 2.7 | 4 | 1.6 | 2.3 | 2.6 | 5.6 | 8.7 | |
| U72661 | Ninjurin 1 | + | + | 1.4 | 3.7 | 7.6 | 10.4 | 1.9 | 3.1 | 6 | 6.3 | 7.8 | |
| U48437 | Amyloid precursor like protein | + | + | 1.9 | 2.7 | 3.7 | 4.7 | 1 | 1.5 | 3.6 | 2.7 | 3.8 | |
| Signal Transduction | |||||||||||||
| J00277 | c-Ha-ras 1 | + | + | 2.3 | 3.1 | 4.7 | 4.8 | 1.2 | 1.5 | 4.1 | 5.6 | 5.7 | |
| X77777 | Intestinal VIPR related protein | + | 14.7 | 7.5 | 11.9 | 9.8 | 1 | 2.7 | 19.9 | 4.7 | 1 | ||
| X62535 | Diacylglycerol Kinase (alpha) | + | + | 4.4 | 12 | 11.2 | 38.8 | 1.2 | 3.4 | 6 | 7.1 | 10.1 | |
| U56998 | Putative ser/thr protein kinase | + | + | 6.3 | 3.6 | 1 | 12.5 | 2.1 | 2.2 | 4.8 | 6.4 | 4.5 | |
| L08835 | DM Kinase | + | 2.5 | 3.4 | 3.3 | 3.7 | 0.9 | 1.2 | 1.8 | 1.5 | 1.5 | ||
| L42176 | DRAL/FHL2 | + | 5.4 | 3.8 | 3.8 | 6.5 | 2 | 2 | 1.8 | 1.5 | 1.7 | ||
| Transcription | |||||||||||||
| L19871 | Activating transcription factor 3 | + | + | 1.4 | 4.4 | 5.9 | 5.2 | 4.2 | 7.2 | 18.9 | 8.8 | 9.9 | |
| U41315 | ZNF127-Xp | + | + | 4.4 | 5.1 | 9.2 | 9.5 | 6.5 | 6.4 | 3.9 | 7.2 | 3.1 | |
| AD000684 | LISCH7 | + | + | 5.2 | 6.1 | 6.1 | 7.4 | 2.7 | 1 | 2.1 | 3.1 | 3.8 | |
| M29580 | Zinc finger protein 7 | + | 1.2 | 2.6 | 3.6 | 4.7 | 1.2 | 1.2 | 1.2 | 1.3 | 1.2 | ||
| U90913 | Tip-1 | + | 3.4 | 2.7 | 3.1 | 3.7 | 1.5 | 2.1 | 2.3 | 1.9 | 2.3 | ||
| HG3494 | Nuclear factor NF-116 | + | 3.3 | 2.4 | 2.9 | 2.7 | 2.9 | 2.8 | 2.4 | 2.3 | 1.1 | ||
| Other | |||||||||||||
| U10099 | POM-ZP3 | + | + | 3.2 | 4.2 | 4.7 | 4.8 | 1.8 | 2 | 4 | 3.5 | 3.3 | |
| D87434 | KIAAA0247 | + | + | 1 | 4.5 | 4.7 | 6.6 | 3.5 | 7.5 | 10.3 | 15.4 | 18.9 | |
| U33147 | Mammaglobin 1 | + | + | 3.5 | 1 | 4.5 | 4.1 | 4.5 | 4.2 | 2.9 | 4.6 | 1 | |
| J05016 | Disulfide isomerase related protein | + | 2.6 | 3.8 | 6 | 8.7 | 2.1 | 1.4 | 1.8 | 1.8 | 2.3 | ||
| U81556 | OS4 | + | 2.7 | 2.6 | 2.4 | 3 | 1.6 | 2.2 | 1.8 | 1.4 | 1.3 | ||
| S58544 | Infertility-related sperm protein | + | 3 | 3.9 | 7.6 | 3.1 | 1.6 | 2 | 1.7 | 3 | 4.3 | ||
| D63481 | KIAA0147 | + | 1.8 | 2.6 | 3.1 | 2.6 | 1.2 | 1.2 | 1.5 | 2.1 | 1.7 | ||
| Z35093 | SURF-1 | + | 2.2 | 2.6 | 2.6 | 3.4 | 1.9 | 2 | 2 | 1.6 | 1.4 | ||
| U94747 | WD repeat protein HAN11 | + | 2.3 | 3.1 | 3.4 | 3.4 | 0.8 | 1.3 | 3 | 1.4 | 3.1 | ||