|
Table1.
Primary target genes up regulated by p53 |
|
|
|
Accession |
|
Ratio of gene
expression at specific time points |
|
No. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-CHX |
|
+CHX |
|
|
|
|
|
hr. |
2 |
6 |
12 |
24 |
2 |
4 |
6 |
9 |
12 |
|
|
|
|
Apoptosis |
G(47) |
G(38) |
G(9) |
|
X63717 |
Fas/APO-1
cell surface antigen |
+ |
+ |
|
2.2 |
5.6 |
7.9 |
8.3 |
3.2 |
6.8 |
3.3 |
5.7 |
9.8 |
U82987 |
Bcl-2 binding
component 3 (bbc3) |
+ |
+ |
|
6.2 |
16.5 |
16.8 |
8.4 |
7.6 |
13.4 |
28.5 |
32.5 |
30.5 |
U00115 |
Bcl-6
|
+ |
+ |
|
2.5 |
3.3 |
5.8 |
6.5 |
3.7 |
4.7 |
6.1 |
6 |
6.8 |
U16811 |
Bak |
+ |
+ |
|
4 |
7 |
4.4 |
6.8 |
1 |
2.3 |
4.5 |
4.7 |
7.4 |
|
Cell Cycle |
|
U09579 |
p21 WAF1 |
+ |
+ |
|
4.3 |
17.98 |
16.9 |
12.97 |
3.5 |
6.7 |
9.2 |
8.2 |
7.4 |
D90070 |
ATL derived
PMA responsive peptide |
+ |
+ |
|
4 |
4.5 |
2.8 |
4.1 |
1.8 |
3.5 |
3.4 |
4.3 |
6.1 |
M60974 |
GADD45 |
+ |
|
|
2.3 |
3.2 |
3.4 |
3.6 |
1.6 |
1.6 |
2.1 |
2.1 |
2 |
|
DNA
Repair/Replication |
|
U72649 |
BTG2 |
+ |
+ |
|
3 |
4.9 |
4.8 |
5.2 |
11 |
15.9 |
20.1 |
17.9 |
16.5 |
U18300 |
Damage-specific
DNA binding protein |
+ |
+ |
|
1.3 |
4 |
5.4 |
7.8 |
1.1 |
2.6 |
8.6 |
6.1 |
9.4 |
U90551 |
Histone
2A-like protein |
+ |
+ |
|
2.6 |
2.6 |
2.5 |
3.5 |
1.7 |
3.1 |
4.5 |
8.8 |
16.7 |
M15796 |
PCNA |
+ |
|
|
2.3 |
3.9 |
5.3 |
5.3 |
1.7 |
1.4 |
1.7 |
1.9 |
3.1 |
|
Receptors/ECM |
|
X72012 |
Endoglin |
|
+ |
|
21.7 |
15.2 |
7.9 |
6.8 |
3.4 |
1 |
14 |
6.9 |
1 |
U16306 |
versican |
+ |
+ |
|
1 |
5.2 |
11.9 |
16.6 |
1 |
2 |
2.7 |
6.8 |
13.3 |
M21904 |
Heavy chain
4F2 |
+ |
|
|
7.7 |
6.5 |
8.2 |
6.1 |
0.9 |
1 |
1.6 |
1.3 |
1.4 |
AF010193 |
SMAD7 |
|
+ |
3.6 |
1.9 |
3.9 |
3.1 |
1.9 |
1.8 |
1.5 |
1.5 |
1.6 |
|
Growth
Factors/Inhibitors |
|
AB000584 |
TGF-Beta
Superfamily Protein |
+ |
+ |
|
3.5 |
41.6 |
67.2 |
50.1 |
11.5 |
16 |
41.4 |
33.6 |
32.4 |
M62402 |
IGFBP6 |
+ |
+ |
|
17.5 |
17.68 |
18.5 |
17.6 |
22.3 |
13.9 |
27.8 |
25.4 |
28.95 |
L42379 |
Quiescin/QSCN6 |
+ |
|
|
2.7 |
2.4 |
2.5 |
2.8 |
1.3 |
2.2 |
2.3 |
2.3 |
1.7 |
X97324 |
Adipophilin |
+ |
|
|
5.2 |
6.3 |
7.1 |
10 |
1.5 |
1.9 |
1.7 |
1.9 |
3.8 |
U72263 |
Multiple
exostoses type II protein |
+ |
|
|
2.9 |
2.7 |
3.1 |
6.2 |
1.5 |
2 |
1.4 |
1.8 |
3.2 |
|
Cytoskeleton/Cell
Adhesion |
|
X13839 |
Vascular
smooth muscle alpha-actin |
+ |
+ |
|
6.5 |
14.6 |
44.3 |
98.3 |
6.4 |
9 |
18.9 |
18.4 |
26.9 |
Z49989 |
Smoothelin |
+ |
+ |
|
3.7 |
4.3 |
3.9 |
3.5 |
1.7 |
2.2 |
4.6 |
4.1 |
3.4 |
X05608 |
Neurofilament
subunit NF-L |
+ |
+ |
|
3 |
7.7 |
16.6 |
32 |
5 |
8.8 |
9.6 |
16.8 |
32.2 |
D82345 |
NB Thymosin
beta |
+ |
+ |
|
2.4 |
3.4 |
4.2 |
5.4 |
1.6 |
2.5 |
3.8 |
2.8 |
3.9 |
X93510 |
LIM domain
protein |
|
+ |
|
4.5 |
5.5 |
4.3 |
5.6 |
4.3 |
2.4 |
9.3 |
3.8 |
1 |
|
Metabolism |
|
|
U24389 |
Lysyl
oxidase-like protein |
+ |
+ |
|
16.7 |
17.5 |
23 |
22.9 |
5.5 |
4.2 |
9.7 |
8.3 |
6.9 |
L41668 |
UDP-Galactose
4 epimerase (GALE) |
+ |
+ |
|
4.2 |
3.6 |
3.2 |
4.4 |
3.2 |
3.7 |
5.1 |
3.4 |
2.8 |
Y12556 |
cAMP
activated Protein Kinase B |
+ |
+ |
|
4 |
1 |
19.7 |
22.2 |
1 |
3.1 |
3.1 |
7.1 |
37.5 |
U05572 |
Lysosomal
Mannosidase alpha B |
|
+ |
|
9.2 |
2 |
7 |
15.9 |
6.5 |
5.6 |
13.9 |
13 |
7.2 |
Y09616 |
Carboxylesterase
(liver) |
+ |
+ |
|
2.3 |
4.1 |
5.9 |
9.1 |
1.9 |
2.5 |
3 |
3.4 |
3.6 |
U78735 |
ABC3 |
|
+ |
4.5 |
3 |
2.8 |
3.6 |
1.9 |
2 |
1.9 |
1.4 |
1.1 |
M20902 |
Apolipoprotein
C-I (VLDL) |
+ |
|
|
3.1 |
3.9 |
2.9 |
4.1 |
2.1 |
2.9 |
2.3 |
2.2 |
1.7 |
U20325 |
CART |
+ |
|
|
2.8 |
3.9 |
3 |
3.3 |
1.3 |
1.7 |
2.1 |
1.3 |
1.9 |
M12625 |
Lecithin-cholesterol
acyltransferase |
+ |
|
|
1.4 |
2.9 |
3 |
3 |
0.8 |
1.4 |
3.6 |
2.6 |
2.4 |
D87292 |
Rhodanese |
|
+ |
7.7 |
4.9 |
5.4 |
10.5 |
1.6 |
1.6 |
1.7 |
1.3 |
1.2 |
|
Neuronal
Growth |
|
|
U35139 |
NECDIN
related protein |
|
+ |
|
3.2 |
1 |
3 |
15.7 |
5.8 |
4.9 |
2.7 |
4.8 |
5.5 |
M96740 |
NSCL-2 gene |
+ |
+ |
|
1 |
4.2 |
10.1 |
12.6 |
2.6 |
2 |
4.8 |
7 |
11 |
U60062 |
FEZ1-T gene |
+ |
+ |
|
1 |
2.7 |
2.7 |
4 |
1.6 |
2.3 |
2.6 |
5.6 |
8.7 |
U72661 |
Ninjurin 1 |
+ |
+ |
|
1.4 |
3.7 |
7.6 |
10.4 |
1.9 |
3.1 |
6 |
6.3 |
7.8 |
U48437 |
Amyloid
precursor like protein |
+ |
+ |
|
1.9 |
2.7 |
3.7 |
4.7 |
1 |
1.5 |
3.6 |
2.7 |
3.8 |
|
Signal
Transduction |
|
J00277 |
c-Ha-ras 1 |
+ |
+ |
|
2.3 |
3.1 |
4.7 |
4.8 |
1.2 |
1.5 |
4.1 |
5.6 |
5.7 |
X77777 |
Intestinal
VIPR related protein |
|
+ |
|
14.7 |
7.5 |
11.9 |
9.8 |
1 |
2.7 |
19.9 |
4.7 |
1 |
X62535 |
Diacylglycerol
Kinase (alpha) |
+ |
+ |
|
4.4 |
12 |
11.2 |
38.8 |
1.2 |
3.4 |
6 |
7.1 |
10.1 |
U56998 |
Putative
ser/thr protein kinase |
+ |
+ |
|
6.3 |
3.6 |
1 |
12.5 |
2.1 |
2.2 |
4.8 |
6.4 |
4.5 |
L08835 |
DM Kinase |
+ |
|
|
2.5 |
3.4 |
3.3 |
3.7 |
0.9 |
1.2 |
1.8 |
1.5 |
1.5 |
L42176 |
DRAL/FHL2 |
|
+ |
5.4 |
3.8 |
3.8 |
6.5 |
2 |
2 |
1.8 |
1.5 |
1.7 |
|
Transcription |
|
L19871 |
Activating
transcription factor 3 |
+ |
+ |
|
1.4 |
4.4 |
5.9 |
5.2 |
4.2 |
7.2 |
18.9 |
8.8 |
9.9 |
U41315 |
ZNF127-Xp |
|
+ |
+ |
4.4 |
5.1 |
9.2 |
9.5 |
6.5 |
6.4 |
3.9 |
7.2 |
3.1 |
AD000684 |
LISCH7 |
+ |
+ |
|
5.2 |
6.1 |
6.1 |
7.4 |
2.7 |
1 |
2.1 |
3.1 |
3.8 |
M29580 |
Zinc finger
protein 7 |
+ |
|
1.2 |
2.6 |
3.6 |
4.7 |
1.2 |
1.2 |
1.2 |
1.3 |
1.2 |
U90913 |
Tip-1 |
+ |
|
|
3.4 |
2.7 |
3.1 |
3.7 |
1.5 |
2.1 |
2.3 |
1.9 |
2.3 |
HG3494 |
Nuclear
factor NF-116 |
|
+ |
3.3 |
2.4 |
2.9 |
2.7 |
2.9 |
2.8 |
2.4 |
2.3 |
1.1 |
|
Other |
|
U10099 |
POM-ZP3 |
+ |
+ |
|
3.2 |
4.2 |
4.7 |
4.8 |
1.8 |
2 |
4 |
3.5 |
3.3 |
D87434 |
KIAAA0247 |
+ |
+ |
|
1 |
4.5 |
4.7 |
6.6 |
3.5 |
7.5 |
10.3 |
15.4 |
18.9 |
U33147 |
Mammaglobin 1 |
|
+ |
+ |
3.5 |
1 |
4.5 |
4.1 |
4.5 |
4.2 |
2.9 |
4.6 |
1 |
J05016 |
Disulfide
isomerase related protein |
+ |
|
|
2.6 |
3.8 |
6 |
8.7 |
2.1 |
1.4 |
1.8 |
1.8 |
2.3 |
U81556 |
OS4 |
|
+ |
2.7 |
2.6 |
2.4 |
3 |
1.6 |
2.2 |
1.8 |
1.4 |
1.3 |
S58544 |
Infertility-related
sperm protein |
+ |
|
|
3 |
3.9 |
7.6 |
3.1 |
1.6 |
2 |
1.7 |
3 |
4.3 |
D63481 |
KIAA0147 |
+ |
|
|
1.8 |
2.6 |
3.1 |
2.6 |
1.2 |
1.2 |
1.5 |
2.1 |
1.7 |
Z35093 |
SURF-1 |
|
+ |
2.2 |
2.6 |
2.6 |
3.4 |
1.9 |
2 |
2 |
1.6 |
1.4 |
U94747 |
WD repeat
protein HAN11 |
+ |
|
2.3 |
3.1 |
3.4 |
3.4 |
0.8 |
1.3 |
3 |
1.4 |
3.1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|