Table1.   Primary target genes up regulated by p53
Accession Ratio of gene expression at specific time points
No.                        
 -CHX  +CHX
        hr. 2 6 12 24 2 4 6 9 12
Apoptosis G(47) G(38) G(9)
X63717 Fas/APO-1 cell surface antigen + + 2.2 5.6 7.9 8.3 3.2 6.8 3.3 5.7 9.8
U82987 Bcl-2 binding component 3 (bbc3) + + 6.2 16.5 16.8 8.4 7.6 13.4 28.5 32.5 30.5
U00115 Bcl-6 + + 2.5 3.3 5.8 6.5 3.7 4.7 6.1 6 6.8
U16811 Bak + + 4 7 4.4 6.8 1 2.3 4.5 4.7 7.4
Cell Cycle
U09579 p21 WAF1 + + 4.3 17.98 16.9 12.97 3.5 6.7 9.2 8.2 7.4
D90070 ATL derived PMA responsive peptide + + 4 4.5 2.8 4.1 1.8 3.5 3.4 4.3 6.1
M60974 GADD45 + 2.3 3.2 3.4 3.6 1.6 1.6 2.1 2.1 2
DNA Repair/Replication
U72649 BTG2 + + 3 4.9 4.8 5.2 11 15.9 20.1 17.9 16.5
U18300 Damage-specific DNA binding protein + + 1.3 4 5.4 7.8 1.1 2.6 8.6 6.1 9.4
U90551 Histone 2A-like protein + + 2.6 2.6 2.5 3.5 1.7 3.1 4.5 8.8 16.7
M15796 PCNA + 2.3 3.9 5.3 5.3 1.7 1.4 1.7 1.9 3.1
Receptors/ECM
X72012 Endoglin + 21.7 15.2 7.9 6.8 3.4 1 14 6.9 1
U16306 versican + + 1 5.2 11.9 16.6 1 2 2.7 6.8 13.3
M21904 Heavy chain 4F2 + 7.7 6.5 8.2 6.1 0.9 1 1.6 1.3 1.4
AF010193 SMAD7 + 3.6 1.9 3.9 3.1 1.9 1.8 1.5 1.5 1.6
Growth Factors/Inhibitors
AB000584 TGF-Beta Superfamily Protein + + 3.5 41.6 67.2 50.1 11.5 16 41.4 33.6 32.4
M62402 IGFBP6 + + 17.5 17.68 18.5 17.6 22.3 13.9 27.8 25.4 28.95
L42379 Quiescin/QSCN6 + 2.7 2.4 2.5 2.8 1.3 2.2 2.3 2.3 1.7
X97324 Adipophilin + 5.2 6.3 7.1 10 1.5 1.9 1.7 1.9 3.8
U72263 Multiple exostoses type II protein + 2.9 2.7 3.1 6.2 1.5 2 1.4 1.8 3.2
Cytoskeleton/Cell Adhesion
X13839 Vascular smooth muscle alpha-actin + + 6.5 14.6 44.3 98.3 6.4 9 18.9 18.4 26.9
Z49989 Smoothelin + + 3.7 4.3 3.9 3.5 1.7 2.2 4.6 4.1 3.4
X05608 Neurofilament subunit NF-L + + 3 7.7 16.6 32 5 8.8 9.6 16.8 32.2
D82345 NB Thymosin beta + + 2.4 3.4 4.2 5.4 1.6 2.5 3.8 2.8 3.9
X93510 LIM domain protein + 4.5 5.5 4.3 5.6 4.3 2.4 9.3 3.8 1
Metabolism
U24389 Lysyl oxidase-like protein + + 16.7 17.5 23 22.9 5.5 4.2 9.7 8.3 6.9
L41668 UDP-Galactose 4 epimerase (GALE) + + 4.2 3.6 3.2 4.4 3.2 3.7 5.1 3.4 2.8
Y12556 cAMP activated Protein Kinase B + + 4 1 19.7 22.2 1 3.1 3.1 7.1 37.5
U05572 Lysosomal Mannosidase alpha B + 9.2 2 7 15.9 6.5 5.6 13.9 13 7.2
Y09616 Carboxylesterase (liver) + + 2.3 4.1 5.9 9.1 1.9 2.5 3 3.4 3.6
U78735 ABC3 + 4.5 3 2.8 3.6 1.9 2 1.9 1.4 1.1
M20902 Apolipoprotein C-I (VLDL) + 3.1 3.9 2.9 4.1 2.1 2.9 2.3 2.2 1.7
U20325 CART + 2.8 3.9 3 3.3 1.3 1.7 2.1 1.3 1.9
M12625 Lecithin-cholesterol acyltransferase + 1.4 2.9 3 3 0.8 1.4 3.6 2.6 2.4
D87292 Rhodanese + 7.7 4.9 5.4 10.5 1.6 1.6 1.7 1.3 1.2
Neuronal Growth
U35139 NECDIN related protein + 3.2 1 3 15.7 5.8 4.9 2.7 4.8 5.5
M96740 NSCL-2 gene + + 1 4.2 10.1 12.6 2.6 2 4.8 7 11
U60062 FEZ1-T gene + + 1 2.7 2.7 4 1.6 2.3 2.6 5.6 8.7
U72661 Ninjurin 1 + + 1.4 3.7 7.6 10.4 1.9 3.1 6 6.3 7.8
U48437 Amyloid precursor like protein + + 1.9 2.7 3.7 4.7 1 1.5 3.6 2.7 3.8
Signal Transduction
J00277 c-Ha-ras 1 + + 2.3 3.1 4.7 4.8 1.2 1.5 4.1 5.6 5.7
X77777 Intestinal VIPR related protein + 14.7 7.5 11.9 9.8 1 2.7 19.9 4.7 1
X62535 Diacylglycerol Kinase (alpha) + + 4.4 12 11.2 38.8 1.2 3.4 6 7.1 10.1
U56998 Putative ser/thr protein kinase + + 6.3 3.6 1 12.5 2.1 2.2 4.8 6.4 4.5
L08835 DM Kinase + 2.5 3.4 3.3 3.7 0.9 1.2 1.8 1.5 1.5
L42176 DRAL/FHL2 + 5.4 3.8 3.8 6.5 2 2 1.8 1.5 1.7
Transcription
L19871 Activating transcription factor 3 + + 1.4 4.4 5.9 5.2 4.2 7.2 18.9 8.8 9.9
U41315 ZNF127-Xp + + 4.4 5.1 9.2 9.5 6.5 6.4 3.9 7.2 3.1
AD000684 LISCH7 + + 5.2 6.1 6.1 7.4 2.7 1 2.1 3.1 3.8
M29580 Zinc finger protein 7 + 1.2 2.6 3.6 4.7 1.2 1.2 1.2 1.3 1.2
U90913 Tip-1 + 3.4 2.7 3.1 3.7 1.5 2.1 2.3 1.9 2.3
HG3494 Nuclear factor NF-116 + 3.3 2.4 2.9 2.7 2.9 2.8 2.4 2.3 1.1
Other
U10099 POM-ZP3 + + 3.2 4.2 4.7 4.8 1.8 2 4 3.5 3.3
D87434 KIAAA0247 + + 1 4.5 4.7 6.6 3.5 7.5 10.3 15.4 18.9
U33147 Mammaglobin 1 + + 3.5 1 4.5 4.1 4.5 4.2 2.9 4.6 1
J05016 Disulfide isomerase related protein + 2.6 3.8 6 8.7 2.1 1.4 1.8 1.8 2.3
U81556 OS4 + 2.7 2.6 2.4 3 1.6 2.2 1.8 1.4 1.3
S58544 Infertility-related sperm protein + 3 3.9 7.6 3.1 1.6 2 1.7 3 4.3
D63481 KIAA0147 + 1.8 2.6 3.1 2.6 1.2 1.2 1.5 2.1 1.7
Z35093 SURF-1 + 2.2 2.6 2.6 3.4 1.9 2 2 1.6 1.4
U94747 WD repeat protein HAN11 + 2.3 3.1 3.4 3.4 0.8 1.3 3 1.4 3.1