Table 3. Primary target genes regulated by p53

-----------------------------------------------------------------------------------------------------------------------------------------------
Accession         Name of the Gene                                                Ratio of Gene Expression at specific time points
No.                                                                         -------------------------------------------------------------------------------------
                                                                                                           - CHX                                     + CHX
                                                                               hr.        2        6          12         24         2         4        6        9        12
------------------------------------------------------------------------------------------------------------------------------------------------
 
Apoptosis
X63717 Fas/APO-1 cell surface antigen
2.2
5.6
7.9
8.3
3.2
6.8
3.3
5.7
9.8
U82987 Bcl-2 binding component 3 (bbc3)
6.2
16.5
16.8
8.4
7.6
13.4
28.5
32.5
30.5
U00115 Bcl-6 
2.5
3.3
5.8
6.5
3.7
4.7
6.1
6
6.8
U16811 Bak
4
7
4.4
6.8
1
2.3
4.5
4.7
7.4
U45878 Inhibitor of Apoptosis protein 1(MIHB)
-4
-8
-3.9
-3.5
-1.9
-1.8
-2.8
-3.1
-2.6
U37546 Inhibitor of Apoptosis protein 2(MIHC)
-4.2
-10.7
-14.9
-15.8
-2.8
-2.8
-3
-3.7
-3.2
Angiogenesis
L22548 Collagen type XVIII alpha 1
-8.4
-8.4
-8.4
-7.6
-2.9
-2.9
-2.9
-2.9
-2.9
Cell Cycle
U09579 p21 WAF1
4.3
17.98
16.9
12.97
3.5
6.7
9.2
8.2
7.4
D90070 ATL derived PMA responsive peptide
4
4.5
2.8
4.1
1.8
3.5
3.4
4.3
6.1
L78833 BRCA-1
-2.9
-3.1
-3.1
-3.1
-4.1
-4.5
-4.5
-2.3
-4.5
M74093 Cyclin E
-0.8
-2.9
-4
-3.2
-1.4
-2.6
-6.9
-4.5
-3.7
U77949 Cdc6-related protein
-2.2
-3.3
-5.9
-6.4
-4.9
-4.4
-9.1
-1.6
-2.1
M72885 GOS2
-33.4
-137
-172
-143
-9.3
-15.1
-11.5
-21
-107
Cytoskeleton/Cell Adhesion
X13839 Vascular smooth muscle alpha-actin
6.5
14.6
44.3
98.3
6.4
9
18.9
18.4
26.9
Z49989 Smoothelin
3.7
4.3
3.9
3.5
1.7
2.2
4.6
4.1
3.4
X05608 Neurofilament subunit NF-L
3
7.7
16.6
32
5
8.8
9.6
16.8
32.2
D82345 NB Thymosin beta
2.4
3.4
4.2
5.4
1.6
2.5
3.8
2.8
3.9
X93510 LIM domain protein
4.5
5.5
4.3
5.6
4.3
2.4
9.3
3.8
1
DNA Repair/Replication
U72649 BTG2
3
4.9
4.8
5.2
11
15.9
20.1
17.9
16.5
U18300 Damage-specific DNA binding protein
1.3
4
5.4
7.8
1.1
2.6
8.6
6.1
9.4
U90551 Histone 2A-like protein
2.6
2.6
2.5
3.5
1.7
3.1
4.5
8.8
16.7
M96684 Purine rich element binding protein A
-4.2
-9.3
-3
-2.5
-1.5
-3.5
-5.3
-5.3
-2.4
Receptors/ECM
X72012 Endoglin
21.7
15.2
7.9
6.8
3.4
1
14
6.9
1
U16306 versican
1
5.2
11.9
16.6
1
2
2.7
6.8
13.3
U31201 Laminin gamma 2 chain
-8.5
-8.5
-8.5
-8.5
-2
-2.7
-7.1
-2.4
-3.9
U90716 Caxsackie virus and adenovirus receptor
-5.4
-3.2
-4.3
-2.5
-2.8
-3
-4.2
-2.3
-1.1
U60975 Receptor gp250 precursor
-2.9
-5.6
-1.9
-3.1
-1.5
-1.3
-6.3
-3.4
-2.8
J04970 Carboxypeptidase M
-6.2
-6.2
-5.8
-6.2
-6.9
-6.9
-6.9
-6.1
-6.9
U17566 Folate transporter
-0.8
-2.8
-10.3
-10.3
-3
-8.8
-10.3
-2.6
-2.5
Growth Factor Inhibitor
AB000584 TGF-Beta Superfamily Protein
3.5
41.6
67.2
50.1
11.5
16
41.4
33.6
32.4
M62402 IGFBP6
17.5
17.68
18.5
17.6
22.3
13.9
27.8
25.4
28.95
Metabolism
U24389 Lysyl oxidase-like protein
16.7
17.5
23
22.9
5.5
4.2
9.7
8.3
6.9
L41668 UDP-Galactose 4 epimerase (GALE)
4.2
3.6
3.2
4.4
3.2
3.7
5.1
3.4
2.8
Y12556 cAMP activated Protein Kinase B
4
1
19.7
22.2
1
3.1
3.1
7.1
37.5
U05572 Lysosomal Mannosidase alpha B
9.2
2
7
15.9
6.5
5.6
13.9
13
7.2
Y09616 Carboxylesterase (liver)
2.3
4.1
5.9
9.1
1.9
2.5
3
3.4
3.6
U00238 Glutamine PRPP amidotransferase
-1.6
-3
-3.5
-3.9
-1.6
-2
-7.2
-9.2
-4.5
Neuronal Growth
U35139 NECDIN related protein
3.2
1
3
15.7
5.8
4.9
2.7
4.8
5.5
M96740 NSCL-2 gene
1
4.2
10.1
12.6
2.6
2
4.8
7
11
U60062 FEZ1-T gene
1
2.7
2.7
4
1.6
2.3
2.6
5.6
8.7
U72661 Ninjurin 1
1.4
3.7
7.6
10.4
1.9
3.1
6
6.3
7.8
U48437 Amyloid precursor like protein
1.9
2.7
3.7
4.7
1
1.5
3.6
2.7
3.8
D11428 Peripheral myelin protein 22
-0.3
-2.7
-2.7
-2.7
-3.5
-2.9
-10.9
-9.2
-10.7
S78296 Neurofilament-66
-5.8
-6.9
-5.1
-6.1
-2.6
-2.6
-6.1
-2.8
-2.2
U79255 Amyloid B-precursor binding protein 
-0.6
-8.3
-8.3
-8.3
-5
-5
-2.5
-5
-5
U73960 ADP-ribosylation factor-like protein 4
-4.7
-3.4
-6.4
-9.8
-1.4
-2.2
-5.9
-5.9
-4.2
Signal Transduction
J00277 c-Ha-ras 1
2.3
3.1
4.7
4.8
1.2
1.5
4.1
5.6
5.7
X77777 Intestinal VIPR related protein
14.7
7.5
11.9
9.8
1
2.7
19.9
4.7
1
X62535 Diacylglycerol Kinase (alpha)
4.4
12
11.2
38.8
1.2
3.4
6
7.1
10.1
U56998 Putative ser/thr protein kinase
6.3
3.6
1
12.5
2.1
2.2
4.8
6.4
4.5
Transcription
L19871 Activating transcription factor 3
1.4
4.4
5.9
5.2
4.2
7.2
18.9
8.8
9.9
U41315 ZNF127-Xp
4.4
5.1
9.2
9.5
6.5
6.4
3.9
7.2
3.1
AD000684 LISCH7
5.2
6.1
6.1
7.4
2.7
1
2.1
3.1
3.8
U80017 Basic transcription factor 2 p44
-2.3
-2.6
-2.7
-3.1
-1.5
-2.2
-8
-4
-3.3
X16706 Fra-2
-1.9
-5.4
-5.4
-5.4
-3.9
-2.8
-2
-1.9
-3.1
Other
U10099 POM-ZP3
3.2
4.2
4.7
4.8
1.8
2
4
3.5
3.3
D87434 KIAAA0247
1
4.5
4.7
6.6
3.5
7.5
10.3
15.4
18.9
U33147 Mammaglobin 1
3.5
1
4.5
4.1
4.5
4.2
2.9
4.6
1
HG2855 HSP 70
-1.9
-2.6
-2.9
-3.4
-1
-1.3
-3.1
-6.9
-20.2
L19183 MAC30
-3.2
-2.9
-3.3
-4
-2
-2.7
-3.8
-2.7
-3.4
AB000467 RES4-25
-2.4
-5
-5
-5
-2.1
-1.1
-6.3
-2.5
-6.3
U79273 Clone 23933
-4.9
-16.3
-2.5
-3.6
-4.2
-4.2
-4.2
-4.2
-2.7

-----------------------------------------------------------------------------------------------------------------------------------------------