Citation read at the conferment of the degree of Doctor of Science, Honoris Causa. to Professor Marvin Edelman by the University of Waterloo, Ontario, Canada, June, 1999
Proteomics Group in collaboration with Vladimir Sobolev (Plant Sciences, WIS)-
studies ligandbinding-site interactions. Software was designed to assist the molecular biologist in understanding the structural consequences of modifying a ligand and/or protein. The approach is based on an analysis of inter-atomic contacts and interface complementarity. Some of the issues dealt with are: binding pocket flexibility and defining consensus binding structures for specific ligands.
Software developed:
lpccsu: Automated analysis of interatomic contacts in proteins
http://bioinfo.weizmann.ac.il:8500/oca-bin/lpccsu
MutaProt: a tool for structural analysis of point mutations
http://bioinfo.weizmann.ac.il/MutaProt/
LigProt: a tool for structural analysis of holo- and apo-protein pairs
http://bioinfo.weizmann.ac.il/ligprot
Projects executed: modeling the binding of tentoxin to plastid ATPase;
conjugation of glutathione with photosystem-II herbicides in glutathione-s-transferase; modeling substrate-enzyme reactions of terpenoid cyclases.
Bioinformatics Service Group in collaboration with Leon Esterman, Shifra Ben-Dor and Eitan Rubin (Bioinformatics & Biological Computing Unit, WIS)-
Coordinates INN: the Israeli National Node of EMBnet, servicing over 2000 researchers nation wide (http://inn.org.il/).
Coordinates ICCBnet: the UNESCO-sponsored network of the International Center for Cooperation in Bioinformatics, providing hands-on bioinformatics training in developing areas such as India, Turkey and Poland (http://www.iccbnet.org/).
Photosystem II Group in collaboration with Autar K. Mattoo (Beltsville,USA) -
studies metabolism and signaling of thylakoid reaction center proteins. Recently, a calcium-dependent but light- and redux-independent enzymatic phosphorylation of PSII proteins was uncovered and the activity characterized. In addition, the complexity of the maturation pathway for the D1 protein was unraveled at a 2D gel level.
see Edelman - Mattoo Photosynthesis Team
continues its ongoing studies to improve the robustness and efficiency of the Spirodela transformation system which was developed in the laboratory.