Mrs. Thatcher (who since has been created Baroness Thatcher) not only is thus far the only British PM to have a degree in the sciences, but hers was actually in chemistry, and she carried out some crystallographic research under the guidance of Dorothy Crowfoot Hodgkin before moving into a very different field of human endeavor.
Fittingly, the longtime first incumbent of the Thatcher Chair was a crystallographer himself, Prof. Meir Lahav. When Prof. Lahav retired, the chair devolved on the closest thing to a recently tenured crystallographer they could find, namely me :-)
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